The energy-dependent proteolysis of cellular proteins is mediated by conserved proteolytic AAA(+) complexes. Two such machines, the m- and i-AAA proteases, are present in the mitochondrial inner membrane. They exert chaperone-like properties and specifically degrade nonnative membrane proteins. However, molecular mechanisms of substrate engagement by AAA proteases remained elusive. Here, we define initial steps of substrate recognition and identify two distinct substrate binding sites in the i-AAA protease subunit Yme1. Misfolded polypeptides are recognized by conserved helices in proteolytic and AAA domains. Structural modeling reveals a lattice-like arrangement of these helices at the surface of hexameric AAA protease ring complexes. Whil...
The vast majority of mitochondrial proteins are synthesized in the cytosol and transported into the ...
AbstractThe inner membrane of mitochondria is one of the protein's richest cellular membranes. The b...
Msp1 is a conserved eukaryotic AAA+ ATPase localized to the outer mitochondrial membrane, where it i...
AbstractMitochondrial AAA proteases play an important role in the maintenance of mitochondrial prote...
Mitochondrial AAA proteases play an important role in the maintenance of mitochondrial proteostasis....
Two membrane-bound ATP-dependent AAA proteases conduct protein quality surveillance in the inner mem...
The mechanism of selective protein degradation of membrane proteins in mitochondria has been studied...
AbstractThe mitochondrial members of the highly conserved AAA family, Yta10p and Yta12p, constitute ...
The AAA domain, a conserved Walker-type ATPase module, is a feature of members of the AAA family of ...
The mitochondrial members of the highly conserved AAA family, Yta10p and Yta12p, constitute a membra...
Ring-shaped AAA+ ATPases control a variety of cellular processes by substrate unfolding and remodeli...
FtsH-related AAA proteases are conserved membrane-anchored, ATP-dependent molecular machines, which ...
FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in ...
AAA proteases are membrane-bound ATP-dependent proteases that are present in eubacteria, mitochondri...
AAA proteases are membrane-bound ATP-dependent proteases that are present in eubacteria, mitochondri...
The vast majority of mitochondrial proteins are synthesized in the cytosol and transported into the ...
AbstractThe inner membrane of mitochondria is one of the protein's richest cellular membranes. The b...
Msp1 is a conserved eukaryotic AAA+ ATPase localized to the outer mitochondrial membrane, where it i...
AbstractMitochondrial AAA proteases play an important role in the maintenance of mitochondrial prote...
Mitochondrial AAA proteases play an important role in the maintenance of mitochondrial proteostasis....
Two membrane-bound ATP-dependent AAA proteases conduct protein quality surveillance in the inner mem...
The mechanism of selective protein degradation of membrane proteins in mitochondria has been studied...
AbstractThe mitochondrial members of the highly conserved AAA family, Yta10p and Yta12p, constitute ...
The AAA domain, a conserved Walker-type ATPase module, is a feature of members of the AAA family of ...
The mitochondrial members of the highly conserved AAA family, Yta10p and Yta12p, constitute a membra...
Ring-shaped AAA+ ATPases control a variety of cellular processes by substrate unfolding and remodeli...
FtsH-related AAA proteases are conserved membrane-anchored, ATP-dependent molecular machines, which ...
FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in ...
AAA proteases are membrane-bound ATP-dependent proteases that are present in eubacteria, mitochondri...
AAA proteases are membrane-bound ATP-dependent proteases that are present in eubacteria, mitochondri...
The vast majority of mitochondrial proteins are synthesized in the cytosol and transported into the ...
AbstractThe inner membrane of mitochondria is one of the protein's richest cellular membranes. The b...
Msp1 is a conserved eukaryotic AAA+ ATPase localized to the outer mitochondrial membrane, where it i...