Area under the curve (AUC) profiles.

The AUC results for receiver operator characteristic (ROC) curves for the prediction of whether or not a cluster would acquire new cases based on recency (collection date) plotted against the distance threshold used to define clustering. The same result was also calculated without a bootstrap requirement for clustering (dashed) and with diagnostic dates used to measure recency (green). The optimal threshold determined in Fig 4 for each data set is marked in red. (TIF)