The self-assembly of prebiotically plausible amphiphiles (fatty acids) to form a bilayer membrane for compartmentalization is an important factor during protocellular evolution. Such fatty acid-based membranes assemble at relatively high concentrations, and they lack robust stability. We have demonstrated that a mixture of lipidated lysine (cationic) and prebiotic fatty acids (decanoic acid, anionic) can form protocellular membranes (amino acid-based membranes) at low concentrations via electrostatic, hydrogen bonding, and hydrophobic interactions. The formation of vesicular membranes was characterized by dynamic light scattering (DLS), pyrene and Nile Red partitioning, cryo-transmission electron microscopy (TEM) images, and glucose encapsu...
Self-assembled membranes composed of both fatty acids and phospholipids are permeable for solutes an...
While modern cell membranes are composed of phospholipids, primitive membranes were probably made fr...
A basic problem in all postulated pathways of prebiotic chemistry is the low concentration which gen...
The prebiotic organization of chemicals into compartmentalized ensembles is an essential step to und...
Early protocells are likely to have arisen from the self-assembly of RNA, peptide, and lipid molecul...
Protoamphiphiles are prebiotically-plausible moieties that would have constituted protocell membrane...
We propose that the first step in the origin of cellular life on Earth was the self-assembly of fatt...
The complexity of the simplest conceivable cell suggests that the chemistry of prebiotic mixtures ne...
AbstractA requirement for concentrated and chemically homogeneous pools of molecular building blocks...
Metal ions strongly affect the self-assembly and stability of membranes composed of prebiotically re...
Fatty acid vesicles may have played a role in the origin of life as a major structural component of ...
International audienceGiant lipid vesicles resemble compartments of biological cells, mimicking them...
Lipids are essential constituents of contemporary living cells, serving as structural molecules that...
It is an open question how the chemical structure of prebiotic vesicle-forming amphiphiles complexif...
It is of great fundamental interest to develop experimental model systems to reconstruct design prin...
Self-assembled membranes composed of both fatty acids and phospholipids are permeable for solutes an...
While modern cell membranes are composed of phospholipids, primitive membranes were probably made fr...
A basic problem in all postulated pathways of prebiotic chemistry is the low concentration which gen...
The prebiotic organization of chemicals into compartmentalized ensembles is an essential step to und...
Early protocells are likely to have arisen from the self-assembly of RNA, peptide, and lipid molecul...
Protoamphiphiles are prebiotically-plausible moieties that would have constituted protocell membrane...
We propose that the first step in the origin of cellular life on Earth was the self-assembly of fatt...
The complexity of the simplest conceivable cell suggests that the chemistry of prebiotic mixtures ne...
AbstractA requirement for concentrated and chemically homogeneous pools of molecular building blocks...
Metal ions strongly affect the self-assembly and stability of membranes composed of prebiotically re...
Fatty acid vesicles may have played a role in the origin of life as a major structural component of ...
International audienceGiant lipid vesicles resemble compartments of biological cells, mimicking them...
Lipids are essential constituents of contemporary living cells, serving as structural molecules that...
It is an open question how the chemical structure of prebiotic vesicle-forming amphiphiles complexif...
It is of great fundamental interest to develop experimental model systems to reconstruct design prin...
Self-assembled membranes composed of both fatty acids and phospholipids are permeable for solutes an...
While modern cell membranes are composed of phospholipids, primitive membranes were probably made fr...
A basic problem in all postulated pathways of prebiotic chemistry is the low concentration which gen...