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Not AvailableWet bubble disease incited by Mycogone perniciosa Magn. in white button mushroom (Agaricus bisporus) is a serious pathogen inflicts heavy damage to the crop, various attempts have been made to manage the disease through various means. Present study is intended to study the interaction of host-pathogen and control measures to reduce the crop losses in button mushroom. Interaction studies between A.bisporus and M.perniciosa conducted in dual, half plate and paired cultures. The average growth of A. bisporus and M.erniciosa in either due culture was 16.13 and 28.86 mm, respectively. Growth of A.bisporus remain unaffected (16.02 mm) and Mycogone enhanced to 36.91 mm (21.80% increase) when both grown in dual culture. Pre-spawning of casing soil with A.bisporus spawn, 5-20 days prior to pasteurization resulted in reduced incidence of wet bubble disease. Thermal death point of Mygone observed to be at 44-45C. Moisture contents of casing soil less than 60% or above at 60C or above temperature. Two bacterial isolates B-9 (Bacillus) and B-18 (Alcaligenes) proved to be very promising bio-control agents for the management of wet bubble disease both under laboratory and mushrooms house conditions. Out of five fungicides and two other chemicals tried, carbendazim proved cost effective in management wet bubble disease among all the fungicides/chemical tested.Not Availabl