Cytotoxic lymphocytes clear infected and transformed cells by releasing the content of lytic granules at cytolytic synapses, and the ability of cytolytic effectors to kill in an iterative manner has been documented previously. Although bidirectional trafficking of cytolytic machinery components along the endosomal pathway has begun to be elucidated, the molecular mechanisms coordinating granule retrieval remain completely unexplored. In the present study, we focus on the lytic granule priming factor Munc13-4, the mutation of which in familial hemophagocytic lymphohistiocytosis type 3 results in a profound defect of cytotoxic function. We addressed the role of phosphatidylinositol (4,5)-bisphosphate (PIP2) in the regulation of Munc13-4 compa...
Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules fr...
Exocytosis is a fundamental cellular process in which contents stored in vesicles are released out o...
International audienceCytotoxic T cells and natural killer cells are crucial for immune surveillance...
International audienceCytotoxic lymphocytes clear infected and transformed cells by releasing the co...
Cytotoxic lymphocytes clear infected and transformed cells by releasing the con-tent of lytic granul...
Although membrane phospholipid phosphatidylinositol-4,5bisphosphate (PIP2) plays a key role as signa...
AbstractSeveral rare human diseases have shed important light on the secretory pathway required for ...
AbstractSecretion of cytolytic granules content at the immunological synapse is a highly regulated p...
In the immune system, degranulation/exocytosis from lymphocytes is crucial for life through facilita...
In the immune system, degranulation/exocytosis from lymphocytes is crucial for life through facilita...
International audienceCytotoxic T lymphocytes and natural killer cells exert their cytotoxic activit...
ABSTRACT Phosphoinositides provide compartment-specific signals for membrane traffick-ing. Plasma me...
The immune system is comprised of specific cell types that communicate and interact via a range of s...
Neutrophils use diverse mechanisms to kill pathogens including phagocytosis, exocytosis, generation ...
International audienceNatural Killer (NK) cells and Cytotoxic T lymphocytes (CTL) are critical for t...
Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules fr...
Exocytosis is a fundamental cellular process in which contents stored in vesicles are released out o...
International audienceCytotoxic T cells and natural killer cells are crucial for immune surveillance...
International audienceCytotoxic lymphocytes clear infected and transformed cells by releasing the co...
Cytotoxic lymphocytes clear infected and transformed cells by releasing the con-tent of lytic granul...
Although membrane phospholipid phosphatidylinositol-4,5bisphosphate (PIP2) plays a key role as signa...
AbstractSeveral rare human diseases have shed important light on the secretory pathway required for ...
AbstractSecretion of cytolytic granules content at the immunological synapse is a highly regulated p...
In the immune system, degranulation/exocytosis from lymphocytes is crucial for life through facilita...
In the immune system, degranulation/exocytosis from lymphocytes is crucial for life through facilita...
International audienceCytotoxic T lymphocytes and natural killer cells exert their cytotoxic activit...
ABSTRACT Phosphoinositides provide compartment-specific signals for membrane traffick-ing. Plasma me...
The immune system is comprised of specific cell types that communicate and interact via a range of s...
Neutrophils use diverse mechanisms to kill pathogens including phagocytosis, exocytosis, generation ...
International audienceNatural Killer (NK) cells and Cytotoxic T lymphocytes (CTL) are critical for t...
Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules fr...
Exocytosis is a fundamental cellular process in which contents stored in vesicles are released out o...
International audienceCytotoxic T cells and natural killer cells are crucial for immune surveillance...