Evaluation of Platelet Indices, PT and PTT in Sudanese Chronic Renal Failure Patients at Khartoum state, 2022

Background: Chronic renal failure is a global public health problem; Kidney transplantation and dialysis are possible solutions of kidney failure.  The aim of our study was to assess the platelet count, platelet indices, prothrombin time (PT) and partial thromboplastin time (PTT) in Sudanese chronic renal failure patients at Khartoum sate, 2022. Materials and Method: This was analytical case control study conducted at Khartoum state. A total of 200 blood samples were collected (100 samples from chronic renal failure patients and 100 healthy individuals from control group). A total of five ml of whole blood was collected from each participant and divided into EDTA anticoagulated tube for platelet count and platelet indices, and into sodium citrate anticoagulated tube. for PT and PTT measurement. Examination of platelet count and platelet indices was done by using Haematology analyser (Sysmex-XP-300), where PT and APTT measurement was done by using coagulation analyser (Coatron-M-1).  Results: The study revealed that in the case group; the mean age was (48.19± 15.53), 42.1% of them were female and 57.1% were male, where in the control group; the mean age was (45.54 ± 16.82), 57.9% were female and 42.9% were male. Regarding to the haematological results; the mean platelet count and PCT of the case group was significantly decreased when compared with the control group with P-value of 0.000. where the mean average of MPV, PDW and PLCR showed no statistically significant differences between cases and control with P-value of > 0.05. According to the PT and PTT; they were increased in the case group when compared with the control group with P-value of 0.000. Conclusion: The study concluded that platelet count and plateletcrit was decreased, where mean platelet volume and platelet distribution width in addition to PLCR, showed no statstically significant difference. PT and PTT were increased in chronic renal failure patients. Keywords: Platelet count, Platelet indices, PT, PTT, chronic renal failure, haemodialysis, bleedin