Efek Pemberian Ekstrak Daun Moringa oleifera terhadap Kadar Kreatinin dan Gambaran Histopatologi Ginjal Tikus Putih Hiperkolesterolemia

ABSTRACT Moringa can be found in some areas of Indonesia and become traditional medicine of South Asia for inflammation, cardiovascular, gastrointestine, hematology, and hepatorenal dissorder. Various compounds with antioxidant potential are found in Moringa leaves, therefore kidney degeneration as a result of hypercholesterolemia and free radicals could be prevented. This study is aimed to understand the effect of Kelor (Moringa oleifera, Lam.) leaves extract to the level of creatinine and histopathological features in the kidneys of hypercholesterolemia rats (Rattus norvegicus). This is a laboratory experimental research using pre and post test with control group design for creatinine measurement and post test only with control group design for histopathology features of kidney, using 28 male rats of Sprague dawley strain. The rats were randomly divided into four groups: control group (KK) were fed with standart pellet, first group (KP1) were hypercholesterolemic rats model without Moringa leaves extract, second group (KP2) were hypercholesterolemic rats model with Moringa leaves extract at dose of 40mg/200gBW, and third group (KP3) were hypercholesterolemic rats model with Moringa leaves extract at dose of 80mg/200gBW. High fat food composition were duck yolk 2cc/200gBW, oxidized oil 1cc/200gBW, and beef tallow 2cc/200gBW. Creatinine level was analyzed with paired T-test and Wilcoxon tests. The histopathological features of the kidney were evaluated based on hydropic degeneration and lipid degeneration of the tubules, analyzed with Mann-Whitney test. There was a significant difference based on Paired T Test between the mean of creatinine level before-after intervention of high fat food (p0,05). Ekstrak etanolik daun kelor dosis 40 mg/200gBB dan dosis 80 mg/200gBB menurunkan kadar kreatinin dan memperbaiki gambaran histopatologi ginjal tikus putih (Rattus norvegicus) hiperkolesterolemia secara bermakna. Kata Kunci: Ekstrak Daun Kelor, Kreatinin, Histopatologi Ginjal, Hiperkolesterolemi