Add to ORKGIn the majority of breast cancer families, DNA testing does not show BRCA1 or BRCA2 mutations and the genetic cause of breast cancer remains unexplained. Routine testing for the CHEK2∗1100delC mutation has recently been introduced in breast cancer families in the Netherlands. The 1100delC mutation in the CHEK2gene may explain the occurrence of breast cancer in about 5% of nonBRCA1/ 2 families in the Netherlands. In the general population the CHEK2∗1100delC mutation confers a slightly increased breast cancer risk, but in a familial breast cancer setting this risk is between 3555% for first degree female carriers. Female breast cancer patients with the CHEK2∗1100delC mutation are at increased risk of contralateral breast cancer and may have a...
Background: CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high preval...
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
In the majority of breast cancer families, DNA testing does not show BRCA1 or BRCA2 mutations and th...
- In the majority of breast cancer families, DNA testing does not show BRCA1 or BRCA2 mutations and ...
Mutations in the CHEK2 gene confer a moderately increased breast cancer risk. The risk for female ca...
textabstractThe 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individ...
The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from No...
Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors f...
The most widely accepted model proposes that familial breast cancer susceptibility is a consequence ...
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been rep...
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been rep...
We recently reported that a sequence variant in the cell-cycle–checkpoint kinase CHEK2 (CHEK2 1100de...
textabstractWe recently reported that a sequence variant in the cell-cycle-c...
textabstractApproximately 15-25% of breast cancers are identified in women with a family history of ...
Background: CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high preval...
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
In the majority of breast cancer families, DNA testing does not show BRCA1 or BRCA2 mutations and th...
- In the majority of breast cancer families, DNA testing does not show BRCA1 or BRCA2 mutations and ...
Mutations in the CHEK2 gene confer a moderately increased breast cancer risk. The risk for female ca...
textabstractThe 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individ...
The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from No...
Mutations in the breast cancer susceptibility genes BRCA1, BRCA2, and CHEK2 are known risk factors f...
The most widely accepted model proposes that familial breast cancer susceptibility is a consequence ...
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been rep...
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been rep...
We recently reported that a sequence variant in the cell-cycle–checkpoint kinase CHEK2 (CHEK2 1100de...
textabstractWe recently reported that a sequence variant in the cell-cycle-c...
textabstractApproximately 15-25% of breast cancers are identified in women with a family history of ...
Background: CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high preval...
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...