The Role of Syzygium Polyanthum Leaf Extract in Reducing Renal Cell Damage with Potassium Oxonate-Induced Hyperuricemia

Background: Kidney is an organ that plays an important role in regulating homeostasis, excrete the foreign or toxic substances, and metabolism product such as uric acid, urea, and creatinine in the body through the urine. Syzygium polyanthum, has been used in lowering uric acid levels. The purpose of this research is to tested the effect of bay leaf extract on kidney histopathology of hyperuricemia induced mice model of potassium oxonate. Methods: This study is a laboratory experimental study with a post-test only control group design, and was divided into a control group, a hyperuricemia (PO) group, an PO group with 75 mg/kg bay leaf extract, an PO group with 150 bay leaf extract and an PO group with 300 mg/kgBW bay leaf extract. The treatment was given for 14 days then histopathological examination of the kidneys was carried out with HE staining. Results: Histopathological inflammation occurred in all groups and necrosis was the most severe found in the positive control group where the administration of bay leaf extract significantly reduced inflammatory cells from the lowest to the highest dose with P < 0.001. Conclusion: Administration of Syzygium polyanthum affected renal histopathology in potassium oxonate-induced hyperuricemic mice