Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction with High-Sensitivity Cardiac Troponin T
- Mueller, C.
- Giannitsis, E.
- Christ, M.
- Ordóñez-Llanos, J.
- Defilippi, C.
- McCord, J.
- Body, R.
- Panteghini, M.
- Jernberg, T.
- Plebani, M.
- Verschuren, F.
- French, John K. (R17588)
- Christenson, R.
- Weiser, S.
- Bendig, G.
- Dilba, P.
- Lindahl, B.
DOIAbstract
Study objective We aim to prospectively validate the diagnostic accuracy of the recently developed 0-h/1-h algorithm, using high-sensitivity cardiac troponin T (hs-cTnT) for the early rule-out and rule-in of acute myocardial infarction. Methods We enrolled patients presenting with suspected acute myocardial infarction and recent (<6 hours) onset of symptoms to the emergency department in a global multicenter diagnostic study. Hs-cTnT (Roche Diagnostics) and sensitive cardiac troponin I (Siemens Healthcare) were measured at presentation and after 1 hour, 2 hours, and 4 to 14 hours in a central laboratory. Patient triage according to the predefined hs-cTnT 0-hour/1-hour algorithm (hs-cTnT below 12 ng/L and Δ1 hour below 3 ng/L to rule out; hs...
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