Unravelling the Role of MPV/platelets Count on Vascular Access Function Among Haemodialysis Egyptian Patients: A Retrospective Single Centre Study

Background and Aims: End-stage kidney disease (ESKD) is a global health problem. It necessitates renal replacement therapy via renal transplantation, peritoneal dialysis, or hemodialysis. Vascular access is mandatory for every patient maintained on hemodialysis. It is a prerequisite for adequate hemodialysis (HD). Platelets play the most important role in securing vascular access function. Patients and Methods: A retrospective cohort study was conducted on 87 patients who underwent intermittent HD via arteriovenous fistula (AVF). Patients were divided into two groups. Group1 (Study group): patients with recent thrombosed AVF within a week of laboratory investigation. Group2 (Control group): patients with well-functioning AVF Evaluation of patients: Results:  The mean platelet volume (MPV), Plateletcrit (PCT), and platelet diameter width (PDW) were 10.43, 0.222, and 13.56 in the study group respectively while in the control group they were 10.11067, 0.201944 and 12.9. MPV/PL count was significant between the two groups. Conclusion: The study found that the larger the platelet indices, the more vascular access malfunctions. The MPV/PL ratio can be used to examine the function of vascular access and estimate its lifespan that continuous monitoring of that ratio might be effective in detecting the risk of AVF in patients receiving regular hemodialysis