Front line treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) and chemotherapy (CHT) results in molecular remission in approximately 95\% of patients tested after consolidation. The small fraction of patients with persistence of molecular disease (i.e. those in whom polymerase chain reaction (PCR) is positive for PML/RARalpha) after such therapy are thought to have a dismal prognosis but has not yet been investigated in detail.We analyzed the clinico-biological features at presentation of APL patients who showed PCR-detectable residual disease and compared them to those of patients achieving molecular remission after AIDA induction and consolidation. Furthermore, we report the outcome of patients with molecu...
Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predic...
Background: Conventional treatment of acute promyelocytic leukemia (APL) including all-trans retinoi...
Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predic...
Front line treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) and c...
©2004, Ferrata Storti Foundation Clinico-biological features and outcome of acute promyelocytic leuk...
All-trans-retinoic acid (ATRA) has greatly modified the prognosis of acute promyelocytic leukemia (A...
Fourteen patients with PML/RARalpha-positive acute promyelocytic leukemia (APL) were given salvage t...
Fourteen patients with PML/RAR alpha-positive acute promyelocytic leukemia (APL) were given salvage ...
Although the majority of patients with acute promyelocytic leukemia (APL) are potentially cured by t...
In spite of the very high cure rate (70%-80%) achieved in APL with combinatorial all-trans retinoic ...
Acute promyelocytic leukemia (APL) is a subtype of acute leukemia characterized by a unique t(15;17)...
Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predic...
Background: Conventional treatment of acute promyelocytic leukemia (APL) including all-trans retinoi...
Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predic...
Front line treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) and c...
©2004, Ferrata Storti Foundation Clinico-biological features and outcome of acute promyelocytic leuk...
All-trans-retinoic acid (ATRA) has greatly modified the prognosis of acute promyelocytic leukemia (A...
Fourteen patients with PML/RARalpha-positive acute promyelocytic leukemia (APL) were given salvage t...
Fourteen patients with PML/RAR alpha-positive acute promyelocytic leukemia (APL) were given salvage ...
Although the majority of patients with acute promyelocytic leukemia (APL) are potentially cured by t...
In spite of the very high cure rate (70%-80%) achieved in APL with combinatorial all-trans retinoic ...
Acute promyelocytic leukemia (APL) is a subtype of acute leukemia characterized by a unique t(15;17)...
Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predic...
Background: Conventional treatment of acute promyelocytic leukemia (APL) including all-trans retinoi...
Reverse-transcription polymerase chain reaction (RT-PCR) of the PML/RAR alpha fusion gene may predic...