Tirucallane-type triterpenoid from the stem bark of <i>Chisocheton lasiocarpus</i> and its cytotoxic activity against MCF-7 breast cancer cells
- Nurlelasari (8413740)
- Samuel San Parulian (14148607)
- Al Arofatus Naini (14148610)
- Erina Hilmayanti (12053590)
- Kindi Farabi (9526120)
- Desi Harneti (2565229)
- Darwati (12053593)
- Tri Mayanti (2565223)
- Rani Maharani (2175566)
- Tati Herlina (4796709)
- Unang Supratman (2565232)
- Risyandi Anwar (14148613)
- Sofa Fajriah (12053596)
- Mohamad Nurul Azmi (3716179)
- Thomas Prescott (14148616)
- Yoshihito Shiono (3624731)
Publication date
November 2022
DOIAbstract
Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures of compounds 1–3 were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound 1 showed the most potent activity (IC50 26.56 ± 1.01 µM) and was two-fold more active than the positive control.</p
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