Individual Ct-values for all treated patients in the E1224-efficacy study over time against predicted Ct-range, the expected counterfactual under the non-treatment assumption.

Individual Ct-values over time by trial arm and time point at each panel. The x-axis represents the individual Ct-value at baseline, and the y-axis represents the individual Ct-value at each time point assessed. Colored areas represent the expected Ct-value range under the no treatment counterfactual for BDZ, E1224-HD8w, E1224-HD4w, E1224-LD8w and placebo, at time-points t0-t4, representing baseline, 2, 4, 6, and 12 months respectively. Colored areas represent predicted counterfactual Ct-values range for a) individuals with alternating detectable/undetectable parasitemia with at least one value under threshold 2 (orange); b) individuals with alternating detectable/undetectable parasitemia with any value over threshold 2 (red); and c) individuals with continuous detectable parasitemia with at least one value over threshold 1 (green).