A theoretical model of the sequence dependent superstructures of DNA

A theoretical model of the sequence dependent superstructures of DNA is proposed on the basis of conformational energy calculations. The model appears to contain the basic physical features for translating the deterministic fluctuations of DNA bases sequences in superstructure elements. The general superstructural features, found in many examples of DNA biologically significative tracts we have investigated, suggest that large scale dynamics, as firstly shown by Careri in the case of enzymes, could be of relevance also in the case of DNA