Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS skin fibroblasts, an outcome that was associated with morphological changes of the nuclei of the cells. Lymphoblasts from HGPS patients also showed increased basal levels of NLRP3 and caspase 1. Consistent with these results, the expression of caspase 1 and Nlrp3, but not of the other inflammasome receptors was higher in the heart and liver of Zmpste24-/- mice, which phenocopy the human disease. These data were further corroborated in LmnaG609G/G609G mice, another HGPS animal model. We also showed that ph...
The NLRP3 inflammasome is a vital part of the innate immune response, whilst its aberrant activation...
SummaryThe hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion o...
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a point mutation in the LMNA gene that acti...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
Abstract Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilf...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford proge...
While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological c...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder characterized by accele...
Abstract Progeroid laminopathies are accelerated aging syndromes caused by defects in nuclear envelo...
Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by prematur...
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-associat...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
Aging is associated with metabolic changes and low-grade inflammation in several organs, which may b...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
The NLRP3 inflammasome is a vital part of the innate immune response, whilst its aberrant activation...
SummaryThe hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion o...
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a point mutation in the LMNA gene that acti...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford proge...
Abstract Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilf...
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford proge...
While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological c...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder characterized by accele...
Abstract Progeroid laminopathies are accelerated aging syndromes caused by defects in nuclear envelo...
Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by prematur...
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-associat...
SummaryDespite a wealth of clinical data showing an association between inflammation and degenerativ...
Aging is associated with metabolic changes and low-grade inflammation in several organs, which may b...
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we ...
The NLRP3 inflammasome is a vital part of the innate immune response, whilst its aberrant activation...
SummaryThe hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion o...
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a point mutation in the LMNA gene that acti...