Detection of circulating tumor DNA using droplet digital polymerase chain reaction (ddPCR) is a highly-sensitive, minimally invasive alternative to serial biopsies for assessment and management of cancer. We used ddPCR to assess the utility of measuring plasma concentrations of common epidermal growth factor receptor (EGFR) mutations (L858R, exon 19 deletion, and T790M) in 57 non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). High baseline plasma EGFR mutation (pEGFRmut) concentrations were associated with shorter progression-free survival (8.43 months) than low baseline pEGFRmut (16.23 months; p = 0.0019). By contrast, there were no differences in tumor shrinkage or overall survival betwee...
IntroductionThe potential to accurately quantify epidermal growth factor receptor (EGFR) mutations i...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
The present study aimed to determine the diagnostic concordance of plasma epidermal growth factor re...
Purpose We studied EGFR mutations in circulating tumor DNA (ctDNA) and explored their role in predic...
PURPOSE: We studied EGFR mutations in circulating tumor DNA (ctDNA) and explored their role in predi...
Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal ...
Background: Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance t...
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Epideral growth factor re...
Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal ...
Background: The validity of epidermal growth factor receptor (EGFR) mutation in serum and plasma DNA...
Over the past years, targeted therapies using tyrosine kinase inhibitors (TKI) have led to an increa...
We hypothesized that plasma-based EGFR mutation analysis for NSCLC may be feasible for monitoring tr...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
Purpose Mutations in the epidermal growth factor receptor ( EGFR) kinase domain can predict tumor...
IntroductionThe potential to accurately quantify epidermal growth factor receptor (EGFR) mutations i...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
The present study aimed to determine the diagnostic concordance of plasma epidermal growth factor re...
Purpose We studied EGFR mutations in circulating tumor DNA (ctDNA) and explored their role in predic...
PURPOSE: We studied EGFR mutations in circulating tumor DNA (ctDNA) and explored their role in predi...
Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal ...
Background: Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance t...
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Epideral growth factor re...
Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal ...
Background: The validity of epidermal growth factor receptor (EGFR) mutation in serum and plasma DNA...
Over the past years, targeted therapies using tyrosine kinase inhibitors (TKI) have led to an increa...
We hypothesized that plasma-based EGFR mutation analysis for NSCLC may be feasible for monitoring tr...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
Purpose Mutations in the epidermal growth factor receptor ( EGFR) kinase domain can predict tumor...
IntroductionThe potential to accurately quantify epidermal growth factor receptor (EGFR) mutations i...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...
The detection of EGFR-sensitizing and EGFR-resistance mutations in advanced non-small-cell lung canc...