Psychophysiological approach in Parkinson's disease: L-dopa effects on preprogramming and control activity
- FATTAPPOSTA F
- PIERELLI F
- MY F
- MOSTARDA M
- DEL MONTE S
- PARISI L
- M. SERRAO
- LOCURATOLO N
- AMABILE G
DOIAbstract
To investigate whether preprogramming (Bereitschaftspotential, BP) and control activity (skilled performance positivity, SPP) in a complex task are sensitive to L-dopa, movement related potentials (MRPs) were recorded in 12 non-demented Parkinson's disease (PD) patients before and after acute L-dopa administration, and in 17 control subjects. After L-dopa administration, the PD patients scored a significantly higher percentage of correct performances ( p<0.05), linked to a decreased BP amplitude ( p<0.001) and an increased SPP amplitude ( p<0.005), than before therapy. Our findings suggest that preprogramming activity is impaired in untreated PD patients. Dopaminergic drug administration seems to restore their ability to use more automatic ...
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