Summary: The cancer research field is finally starting to unravel the mystery behind why males have a higher incidence and mortality rate than females for nearly all cancer types of the non-reproductive systems. Here, we explain how sex – specifically sex chromosomes and sex hormones – drives differential adaptive immunity across immune-related disease states including cancer, and why males are consequently more predisposed to tumor development. We highlight emerging data on the roles of cell-intrinsic androgen receptors in driving CD8+ T cell dysfunction or exhaustion in the tumor microenvironment and summarize ongoing clinical efforts to determine the impact of androgen blockade on cancer immunotherapy. Finally, we outline a framework for...
Androgen signaling compromises CD8 <sup>+</sup> T cell effector functions and contribute...
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action...
Nowadays, several types of tumors can benefit from the new frontier of immunotherapy, due to the rec...
Sex is a biological variable with significant influence on immune function (3). However, immunologic...
Cancer is one of the complex disorders that show sexual dimorphism in its susceptibility, clinical c...
The incidence of many types of cancer arising in organs with non-reproductive functions is significa...
Investigating sex differences in cancer will improve therapy for both sexes and discover sex-specifi...
The impact of sex hormones on anticancer immunity deserves attention due to the importance of the im...
The immune system plays an important role in the development of cancer, and immune cells have recent...
The incidence of many types of cancer arising in organs with non-reproductive functions is significa...
We now know that cancer is many different diseases, with great variation even within a single histol...
UNLABELLED: Sex differences in glioblastoma (GBM) incidence and outcome are well recognized, and eme...
Cancer represents a significant cause of death and suffering in both the developed and developing co...
INTRODUCTION: Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for multiple ...
There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment ...
Androgen signaling compromises CD8 <sup>+</sup> T cell effector functions and contribute...
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action...
Nowadays, several types of tumors can benefit from the new frontier of immunotherapy, due to the rec...
Sex is a biological variable with significant influence on immune function (3). However, immunologic...
Cancer is one of the complex disorders that show sexual dimorphism in its susceptibility, clinical c...
The incidence of many types of cancer arising in organs with non-reproductive functions is significa...
Investigating sex differences in cancer will improve therapy for both sexes and discover sex-specifi...
The impact of sex hormones on anticancer immunity deserves attention due to the importance of the im...
The immune system plays an important role in the development of cancer, and immune cells have recent...
The incidence of many types of cancer arising in organs with non-reproductive functions is significa...
We now know that cancer is many different diseases, with great variation even within a single histol...
UNLABELLED: Sex differences in glioblastoma (GBM) incidence and outcome are well recognized, and eme...
Cancer represents a significant cause of death and suffering in both the developed and developing co...
INTRODUCTION: Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for multiple ...
There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment ...
Androgen signaling compromises CD8 <sup>+</sup> T cell effector functions and contribute...
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action...
Nowadays, several types of tumors can benefit from the new frontier of immunotherapy, due to the rec...