Antimicrobial polyurethanes containing an association of antibiotics

In this work, surface minimizing the risk of device-associated infections, through antibiotic adsorption on suitably modified biocompatible polymeric materials were developed. To improve the resistance of the device to microbial infections, a combination of two antibiotics, cefamandole nafate (CEF) and a rifampin (RIF), having different action mechanisms, were adsorbed on functionalized polyurethane films. Antibiotic release increased by adding, as pore formers, polyethylenglycol (PEG) of a different molecular weight