Ultrasound-guided fine needle aspiration versus non-aspiration techniques in the evaluation of solid thyroid nodules

Abstract Background Comparison between the Fine Needle Non-Aspiration Cytology (FNNAC) and Fine Needle Aspiration Cytology (FNAC) in acquiring ultrasound-guided fine needle cytology (FNC) samples from solid thyroid nodules to determine the better technique, hence improving the sample quality aiming to decrease the number of unnecessary thyroidectomy operations. Results Prospective study showed statistically significant increase in cellular yield, preservation of cellular architecture and decrease in cellular trauma along with statistically significant increase in total sample quality with FNNAC (P value = 0.32, 0.004, 0.011, 0.21 respectively), and statistically insignificant difference in background blood in the sample (P value = 0.8). Regarding sample convenience, FNNAC was found to be more convenient for both the patient (syringe is not seen by the patient reducing discomfort) and for the operator (better handling of the needle and fewer maneuvres). Conclusions FNC is an approved sensitive and cost-effective method to evaluate thyroid nodules, FNNAC technique was found to be more convenient for both the patient and the operator with statistically significant improvement in total sample quality compared to FNAC