Abstract Background Leptin exerts both protective and deleterious effects on the heart; the first occurs under hypoxia- or ischemia-associated damage, the second is a pro-hypertrophic factor on cardiomyocytes. Therefore, leptin could represent a link between obesity and cardiovascular diseases. The study aimed to investigate the effect of leptin—the same concentration that is frequently measured in obesity and induces cardiac hypertrophy—on murine hearts following an episode of ischemia–reperfusion; moreover, we evaluated the heart's performance, hypertrophy, and activation of apoptosis. Rat hearts were perfused continuously with or without 3.1 nM leptin for one h before and 1 h after an episode of ischemia. Cardiac performance was evaluate...
<div><p>Rationale</p><p>High-fat diet with obesity-associated co-morbidities triggers cardiac remode...
Background and Purpose— Leptin is an adipose hormone endowed with angiopoietic, neurotrophic, and ne...
Background—Increased circulating leptin is present in human heart failure, and leptin deficiency is ...
Background. Functional receptors for leptin were described on the surface of cardiomyocytes, and the...
BACKGROUND:Acute MI induces leptin expression in the heart, however the role of myocardial leptin in...
Leptin, is a 16 kDa pleiotropic peptide not only primarily secreted by adipocytes, but also produced...
Leptin, is a 16 kDa pleiotropic peptide not only primary secreted by adipocytes, but also produced b...
Leptin is an adipocytokine that reduces ischemic damage in several organs including brain and heart....
International audienceLeptin is known to exert cardiodepressive effects and to induce left ventricul...
Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertensi...
International audienceIschemic postconditioning (IPCD) significantly reduces infarct size in healthy...
OBJECTIVE—ob/ob and db/db mice manifest myocardial hyper-trophy, insulin resistance, altered substra...
dissertationLeptin is a hormone produced by adipocytes that activates centralreceptors in the brain ...
Leptin has been hypothesized to be a pathophysiologic link between obesity and cardiovascular diseas...
Background and aims: Leptin resistance or leptin signalling deficiency are associated with increased...
<div><p>Rationale</p><p>High-fat diet with obesity-associated co-morbidities triggers cardiac remode...
Background and Purpose— Leptin is an adipose hormone endowed with angiopoietic, neurotrophic, and ne...
Background—Increased circulating leptin is present in human heart failure, and leptin deficiency is ...
Background. Functional receptors for leptin were described on the surface of cardiomyocytes, and the...
BACKGROUND:Acute MI induces leptin expression in the heart, however the role of myocardial leptin in...
Leptin, is a 16 kDa pleiotropic peptide not only primarily secreted by adipocytes, but also produced...
Leptin, is a 16 kDa pleiotropic peptide not only primary secreted by adipocytes, but also produced b...
Leptin is an adipocytokine that reduces ischemic damage in several organs including brain and heart....
International audienceLeptin is known to exert cardiodepressive effects and to induce left ventricul...
Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertensi...
International audienceIschemic postconditioning (IPCD) significantly reduces infarct size in healthy...
OBJECTIVE—ob/ob and db/db mice manifest myocardial hyper-trophy, insulin resistance, altered substra...
dissertationLeptin is a hormone produced by adipocytes that activates centralreceptors in the brain ...
Leptin has been hypothesized to be a pathophysiologic link between obesity and cardiovascular diseas...
Background and aims: Leptin resistance or leptin signalling deficiency are associated with increased...
<div><p>Rationale</p><p>High-fat diet with obesity-associated co-morbidities triggers cardiac remode...
Background and Purpose— Leptin is an adipose hormone endowed with angiopoietic, neurotrophic, and ne...
Background—Increased circulating leptin is present in human heart failure, and leptin deficiency is ...