Enantioselective semi-preparative HPLC of two arylpropionic acids on glycopeptides containing chiral stationary phases

A new enantioselective HPLC procedure for the direct semi-preparative resoln. of two unmodified 2-arylpropionic acids is described. The method is based on the use of novel lab.-made chiral stationary phases (CSPs) contg. macrocyclic glycopeptide antibiotics, such as teicoplanin A2-2 and A-40,926, covalently bonded to silica gel microparticles. The new CSPs showed high enantioselectivities and broad applicabilities for sepns. on a semi-preparative scale. [on SciFinder(R)