The maintenance of the differentiated hepatocyte phenotype and its specific physiological properties is known to depend on several factors, such as chemical signals, cell-cell and extracellular matrix molecular interactions, as well as the use of three-dimensional matrices. The entrapment of hepatocytes within Ca-alginate at high cell density and the culture under continuous flow favour the development of three-dimensional organization and promote expression of the differentiated hepatic phenotype. This system could represent an improvement in hepatocyte cultivation for basic studies of liver physiology and metabolism; it could also be applicable in toxicology, hepatocyte transplantation or development of bioartificial organs. This report d...
Liver failure is a life threatening condition. A large problem in the manufacturing of synthetic liv...
Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive opt...
The homogeneous expansion behaviour of liquid-fluidized beds is exploited in various fields such as ...
We studied the effect of continuous medium flow on the viability and structural organization of hepa...
The maintenance of differentiated hepatocyte phenotype in vitro depends on several factors-in partic...
International audienceThree-dimensional (3D) culture systems have been introduced to provide cells w...
Dottorato di Ricerca in Scienze ed Ingegneria dell'Ambiente, delle Costruzioni e dell'Energia (SIACE...
In vitro 3D hepatocyte culture constitutes a core aspect of liver tissue engineering. However, conve...
Liver in vitro systems that allow reliable prediction of major human in vivo metabolic pathways have...
Liver tissue constructs with excretory function are crucial to developing realistic hepatocyte model...
Liver cell therapy and in vitro models require functional human hepatocytes, the sources of which ar...
Liver is the largest organ of the human body; it fulfills hundreds of viable functions, and could be...
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, February 2...
In the whole animal, metabolic regulations are set by reciprocal interactions between various organs...
Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive opt...
Liver failure is a life threatening condition. A large problem in the manufacturing of synthetic liv...
Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive opt...
The homogeneous expansion behaviour of liquid-fluidized beds is exploited in various fields such as ...
We studied the effect of continuous medium flow on the viability and structural organization of hepa...
The maintenance of differentiated hepatocyte phenotype in vitro depends on several factors-in partic...
International audienceThree-dimensional (3D) culture systems have been introduced to provide cells w...
Dottorato di Ricerca in Scienze ed Ingegneria dell'Ambiente, delle Costruzioni e dell'Energia (SIACE...
In vitro 3D hepatocyte culture constitutes a core aspect of liver tissue engineering. However, conve...
Liver in vitro systems that allow reliable prediction of major human in vivo metabolic pathways have...
Liver tissue constructs with excretory function are crucial to developing realistic hepatocyte model...
Liver cell therapy and in vitro models require functional human hepatocytes, the sources of which ar...
Liver is the largest organ of the human body; it fulfills hundreds of viable functions, and could be...
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, February 2...
In the whole animal, metabolic regulations are set by reciprocal interactions between various organs...
Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive opt...
Liver failure is a life threatening condition. A large problem in the manufacturing of synthetic liv...
Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive opt...
The homogeneous expansion behaviour of liquid-fluidized beds is exploited in various fields such as ...