A large body of evidence points to a pivotal relationship between Th-1 cells and mucosal inflammation in Crohn's disease (CD). The aim of the present study was to assess whether CD is associated with specific functional activity of lamina propria T lymphocytes (LPT), particularly purified CD4, such as cytotoxic activity and specific cytokine-secreted profile. The results showed that CD4 LPT in patients displayed a chronically activated memory-like surface phenotype and, when compared to controls, had a significantly enhanced antibody-redirected cytotoxicity. Interestingly, the ratio of perforin expression in CD4 LPT was higher compared to controls, and a redirected lysis of human RBC mediated by a CD4 subset of intestinal lamina propria was...
Recently, the alteration of peripheral T cells has become a focus of attention in research on Crohn'...
<p>(<b>A</b>) CD4 T cell subsets were examined in PBMC, mLNs and LPMC of patients with Crohn’s disea...
The importance of CD45RB expression on T cells was already shown in mice where CD45RB(high) expressi...
Background & AimsCrohn’s disease (CD) has been associated with an altered immune response to commens...
The role of cell-mediated cytotoxicity in the pathogenesis of ulcerative colitis and Crohn's disease...
The contribution of cell-mediated cytotoxicity to the pathogenesis of inflammatory bowel disease (IB...
Crohn’s Disease (CD)-associated inflammation is supposed to be driven by T helper (Th)1/Th17 cell-de...
The role of cell-mediated cytotoxicity in the pathogenesis of ulcerative colitis and Crohn's disease...
Crohn's disease (CD) is a chronic granulomatous inflammation of the intestine. The etiology is unkno...
Thirty years of research on the role of immune-mediated cytotoxic activity in the tissue injury of i...
Background: Activated lymphocytes are considered to play a pathogenic role in Crohn's disease (CD) a...
Using two colour immunofluorescence with fluorescein isothiocyanate and phycoerythrin labelled monoc...
Crohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. A...
Inflammatory bowel disease is a chronic, relapsing inflammation of the intestine. Approximately 0.5%...
A breakdown of intestinal homeostasis due to dysregulated immune responses against intestinal bacter...
Recently, the alteration of peripheral T cells has become a focus of attention in research on Crohn'...
<p>(<b>A</b>) CD4 T cell subsets were examined in PBMC, mLNs and LPMC of patients with Crohn’s disea...
The importance of CD45RB expression on T cells was already shown in mice where CD45RB(high) expressi...
Background & AimsCrohn’s disease (CD) has been associated with an altered immune response to commens...
The role of cell-mediated cytotoxicity in the pathogenesis of ulcerative colitis and Crohn's disease...
The contribution of cell-mediated cytotoxicity to the pathogenesis of inflammatory bowel disease (IB...
Crohn’s Disease (CD)-associated inflammation is supposed to be driven by T helper (Th)1/Th17 cell-de...
The role of cell-mediated cytotoxicity in the pathogenesis of ulcerative colitis and Crohn's disease...
Crohn's disease (CD) is a chronic granulomatous inflammation of the intestine. The etiology is unkno...
Thirty years of research on the role of immune-mediated cytotoxic activity in the tissue injury of i...
Background: Activated lymphocytes are considered to play a pathogenic role in Crohn's disease (CD) a...
Using two colour immunofluorescence with fluorescein isothiocyanate and phycoerythrin labelled monoc...
Crohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. A...
Inflammatory bowel disease is a chronic, relapsing inflammation of the intestine. Approximately 0.5%...
A breakdown of intestinal homeostasis due to dysregulated immune responses against intestinal bacter...
Recently, the alteration of peripheral T cells has become a focus of attention in research on Crohn'...
<p>(<b>A</b>) CD4 T cell subsets were examined in PBMC, mLNs and LPMC of patients with Crohn’s disea...
The importance of CD45RB expression on T cells was already shown in mice where CD45RB(high) expressi...