Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular regulatory mechanisms remain unfolded. Here, we report that congenital ablation of the microRNA-synthesizing enzyme, Dicer, in Kiss1 cells, causes late-onset hypogonadotropic hypogonadism in both sexes, but is compatible with pubertal initiation and preserved Kiss1 neuronal populations at the infantile/juvenile period. Yet, failure to complete puberty and attain fertility is observed only in females. Kiss1-specific ablation of Dicer evokes disparate changes of Kiss1-cell numbers and Kiss1/kisspeptin expression between hypothalamic subpopulations during the pubertal-transition, with a predominant decline in arcuate-nucleus Kiss1 levels, linked ...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
The adipocyte-derived hormone leptin is required for normal pubertal maturation in mice and human...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular r...
Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular r...
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central re...
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and ide...
Thesis (Ph.D.)--University of Washington, 2013A network of hypothalamic neurons integrates signals f...
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion....
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and ide...
Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen fee...
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion....
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central re...
MATERIALS AND METHODS : A detailed description of methodologies—including the use of transgenic mous...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
The adipocyte-derived hormone leptin is required for normal pubertal maturation in mice and human...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular r...
Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular r...
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central re...
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and ide...
Thesis (Ph.D.)--University of Washington, 2013A network of hypothalamic neurons integrates signals f...
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion....
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and ide...
Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen fee...
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion....
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central re...
MATERIALS AND METHODS : A detailed description of methodologies—including the use of transgenic mous...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...
The adipocyte-derived hormone leptin is required for normal pubertal maturation in mice and human...
L’article original est publié par The Endocrine SocietyKisspeptin (Kiss1) signaling to GnRH neurons ...