Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
- Pedersen O
- Lim EM
- Visser WE
- Brown SJ
- Linneberg A
- Volzke H
- Mikolajczyk R
- Pramstaller PP
- Taliun D
- Rivadeneira F
- Pattaro C
- Boerwinkle E
- Kubo M
- Kajantie E
- Walsh JP
- Haljas K
- Kasbohm E
- Rawal R
- Kottgen A
- Cucca F
- Kiemeney LA
- Jensen RA
- Okadah Y
- Eriksson JG
- Homuth G
- Postmus I
- Wilson SG
- Psaty BM
- Starr JM
- Arking DE
- Ittermann T
- Astrup A
- zu Schwabedissen HEM
- Ekici AB
- Rotter JI
- Fiorillo E
- Peeters RP
- Gieger C
- den Heijer M
- Wolffenbuttel BHR
- Marina M
- Medenwald D
- Lapauw B
- Appel EVR
- Liewald DCM
- Zheng HF
- Yang Q
- Medici M
- Galesloot TE
- Akiyama M
- Campbell PJ
- Sanna S
- Sorensen TIA
- De Meyer T
- Ikrarm MA
- Fiers T
- Porcu E
- Naitza S
- Kloppenburg M
- Stott DJ
- Uitterlinden AG
- Roef G
- Kronenberg F
- Grarup N
- Ford I
- Li S
- Lahti J
- Barbieri C
- Schlessinger D
- Richards JB
- Sala CF
- Fox CS
- Rietzschel ER
- Spector TD
- Toniolo D
- Cerqueira C
- Taes Y
- van Heemst D
- Thuesen B
- Tiller D
- Kaufman JM
- De Buyzere M
- Deary IJ
- Deelen J
- den Hollander W
- Pala M
- Fuchsberger C
- Ramos YFM
- Di Munno C
- Meisinger C
- Hui JN
- Nolte IM
- Harris SE
- Arnold A
- Ahluwalia TS
- Meulenbelt I
- Jukema JW
- Netea-Maier RT
- De Grandi A
- Soranzo N
- Bekaert S
- Moed M
- Groeneweg S
- Tanaka T
- Mascalzoni D
- Teumer A
- Beekman M
- Kamatani Y
- Gogele M
- Traglia M
- Cappola A
- Hicks AA
- Jing J
- Li Y
- Petersmann A
- Beilby JP
- Chaker L
- Greiser KH
- Hansen T
- Eckardt KU
- Redmond P
- Selvin E
- Ceresini G
- Ferrrucci L
- Matsuda K
- Visser TJ
- Schultheiss UT
- Slagboom PE
DOIAbstract
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subcli...
Add to ORKG