Objective:Despite its numerous side effects, clozapine is still the most effective antipsychotics making it an ideal reference substance to validate the efficacy of novel compounds for the treatment of schizophrenia. However, blood–brain barrier permeability for most new molecular entities is unknown, requiring central delivery. Thus, we performed a dose-finding study for chronic intracerebroventricular (icv) delivery of clozapine in mice.Methods:Specifically, we implanted wild-type C57BL/6J mice with osmotic minipumps (Alzet) delivering clozapine at a rate of 0.15 µl/h at different concentrations (0, 3.5, 7 and 14 mg/ml, i.e. 0, 12.5, 25 and 50 µg/day). Mice were tested weekly in a modified SHIRPA paradigm, for locomotor activity in the op...
The designer receptor exclusively activated by designer drugs (DREADD) system is one of the most wid...
Schizophrenia is a disabling mental illness that affects approximately 1% of the world population. T...
The complex pathophysiology of brain disorders and the difficulty of delivering therapeutic agents t...
Clozapine, by virtue of its absence of extrapyramidal side effects and greater efficacy, revolutioni...
Rationale: Prepulse inhibition (PPI) of startle refers to the phenomenon in which a weak prepulse at...
BACKGROUND: Clozapine is highly effective in treatment-resistant schizophrenia, although, there rema...
Rationale: Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a parad...
International audienceINTRODUCTION: Recent studies have suggested that schizophrenia is associated w...
Rationale: The atypical antipsychotic drug (APD) clozapine (CLZ) has been shown to have a robust dis...
<p>A) S1/2<sup>-/-</sup> mice display impairment of PPI (E<sub>genotype</sub> F<sub>(1,43)</sub> = 7...
Background: Schizophrenia and related disorders such as schizophreniform and schizoaffective disorde...
The weak base antipsychotic clozapine is the most effective medication for treating refractory schiz...
Designer receptors exclusively activated by designer drugs (DREADDs) are popular tools used to manip...
Background: Clozapine, an atypical antipsychotic medication, has been effectively used to treat refr...
Neurotransmitter switching (NTS) is a form of neuroplasticity in which a neuron loses the neurotrans...
The designer receptor exclusively activated by designer drugs (DREADD) system is one of the most wid...
Schizophrenia is a disabling mental illness that affects approximately 1% of the world population. T...
The complex pathophysiology of brain disorders and the difficulty of delivering therapeutic agents t...
Clozapine, by virtue of its absence of extrapyramidal side effects and greater efficacy, revolutioni...
Rationale: Prepulse inhibition (PPI) of startle refers to the phenomenon in which a weak prepulse at...
BACKGROUND: Clozapine is highly effective in treatment-resistant schizophrenia, although, there rema...
Rationale: Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a parad...
International audienceINTRODUCTION: Recent studies have suggested that schizophrenia is associated w...
Rationale: The atypical antipsychotic drug (APD) clozapine (CLZ) has been shown to have a robust dis...
<p>A) S1/2<sup>-/-</sup> mice display impairment of PPI (E<sub>genotype</sub> F<sub>(1,43)</sub> = 7...
Background: Schizophrenia and related disorders such as schizophreniform and schizoaffective disorde...
The weak base antipsychotic clozapine is the most effective medication for treating refractory schiz...
Designer receptors exclusively activated by designer drugs (DREADDs) are popular tools used to manip...
Background: Clozapine, an atypical antipsychotic medication, has been effectively used to treat refr...
Neurotransmitter switching (NTS) is a form of neuroplasticity in which a neuron loses the neurotrans...
The designer receptor exclusively activated by designer drugs (DREADD) system is one of the most wid...
Schizophrenia is a disabling mental illness that affects approximately 1% of the world population. T...
The complex pathophysiology of brain disorders and the difficulty of delivering therapeutic agents t...