Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion
- Prudhomme M
- Rainio EM
- Koskinen PJ
- Vahakoski RL
- Anizon F
- Sandholm JA
- Santio NM
- Virtanen SS
- Moreau P
Publication date
October 2022
DOI Publisher
Springer Science and Business Media LLC Journal
Molecular CancerAbstract
Conclusions: Altogether, our data indicate that DHPCC-9 is not only a powerful tool to investigate physiological effects of the oncogenic Pim family kinases, but also an attractive molecule for drug development to inhibit invasiveness of Pim-overexpressing cancer cells
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