Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior urethral valves (PUV), a male limited anatomical obstruction of the urethra affecting 1 in 4,000 male live births. Little is known about the genetic background of PUV. Here, we report the largest genome-wide association study (GWAS) for PUV in 4 cohorts of patients and controls. The final meta-analysis included 756 patients and 4,823 ethnicity matched controls and comprised 5,754,208 variants that were genotyped or imputed and passed quality control in all 4 cohorts. No genome-wide significant locus was identified, but 33 variants showed suggestive significance (P < 1 × 10−5). When considering only loci with multiple variants residing within < 10 kB ...
Three genome-wide association studies in Europe and the USA have reported eight urinary bladder canc...
Vesico-ureteral reflux (VUR) is the retrograde passage of urine from the bladder to the urinary trac...
Context Although family studies have shown that male lower urinary tract symptoms (LUTS) are highly...
Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior urethral valve...
Posterior urethral valves (PUV) are the commonest cause of end-stage renal disease in children, but ...
Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are conge...
The cause of posterior urethral valves (PUV) is unknown, but genetic factors are suspected given the...
Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are conge...
OBJECTIVE: The aim of the present study was to investigate genetic effects in the formation of co...
WOS: 000230353300002PubMed ID: 15912376Lower urinary tract obstruction by posterior urethral valves ...
Three genome-wide association studies in Europe and the USA have reported eight urinary bladder canc...
Vesico-ureteral reflux (VUR) is the retrograde passage of urine from the bladder to the urinary trac...
Context Although family studies have shown that male lower urinary tract symptoms (LUTS) are highly...
Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior urethral valve...
Posterior urethral valves (PUV) are the commonest cause of end-stage renal disease in children, but ...
Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are conge...
The cause of posterior urethral valves (PUV) is unknown, but genetic factors are suspected given the...
Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are conge...
OBJECTIVE: The aim of the present study was to investigate genetic effects in the formation of co...
WOS: 000230353300002PubMed ID: 15912376Lower urinary tract obstruction by posterior urethral valves ...
Three genome-wide association studies in Europe and the USA have reported eight urinary bladder canc...
Vesico-ureteral reflux (VUR) is the retrograde passage of urine from the bladder to the urinary trac...
Context Although family studies have shown that male lower urinary tract symptoms (LUTS) are highly...