Nearly three decades since its seminal Chevron decision, the Supreme Court has yet to articulate clearly how that case’s doctrine of deference to agency statutory interpretations applies to one of the most important federalism issues of our time: regulatory preemption of state law. When statutory language is ambiguous – a signal under Chevron of congressional intent to delegate interpretive authority – should courts also defer to agency interpretations finding preemption? Or does preemption require a specialized approach? The Court has approached its preemption decisions cautiously, wishing to avoid altering the federal-state balance of power without express congressional authorization. Accordingly, it has deferred to agency interpretatio...