Many factors will determine whether President-Elect Joe Biden and Vice President-Elect Kamala Harris can deliver on their policy agenda, but few are as important as their ability to leverage the federal regulatory system. Given the prospect of a divided U.S. Congress, the most viable path for significant progress is through effective implementation of existing statutory authorities. We urge Biden and Harris to institute fundamental cross-cutting reforms for building a people-centered regulatory system that is fairer, more equitable, and more effective. Upon assuming office in January, Biden and Harris will face a daunting confluence of policy crises, including the COVID-19 pandemic and the ensuing economic downturn, systemic racial injusti...