A study on meibomian gland carcinoma in a tertiary care hospital, Hyderabad

Background: Sebaceous gland tumour is the second commonest tumour of meibomian glands of eye. Presence of other similar ocular conditions of eye, the diagnosis of the disease is usually late. It is more common in old age and more common in women. In one third of the cases, the common site of origin is upper eye lid and may invade overlying epithelium. This condition is multicentric origin and hedge biopsy is needed to confirm the case. Pleomorphic cells with hyperchromatic nuclei and vacuolated nuclei were seen. Wedge biopsy of the lesion from multiple sites is diagnostic of the condition. Cytoplasm is foamy due to fat content. Objective: To study the incidence and clinical behaviour of meibomian gland carcinoma of the lid in patients attending outpatient department of sarojini devi eye hospital, Hyderabad Methods: The present study titled “meibomian gland carcinoma” was a prospective interventional case series study undertaken in patients who attended oculoplasty department , Sarojini devi eye hospital, Hyderabad, between December 2011 to October 2013. The study included 90 eyes of 90 consecutive patients presented with lid swelling who were diagnosed on the basis of history, clinical symptoms and signs, and by histopathological examination as eyelid malignancy. Among these 47 were meibomian gland carcinoma. Cases were treated surgically using standard protocol. Post operative results and follow up were recorded. Results were analysed using statistical parameters. Results: Total number of eyes studied 90 in consecutive cases and 80% of them in the age group of 50-70 years. 60% of the studied cases were females. In 55% of the eyes, left eye was involved. Upper lid was involved in 72% cases. Lower lid was involved in 25% of cases. Excision of tumor and lid constructive surgery was done in 92% of cases. In 52% of cases, the histopathological diagnosis was Meibomian Gland Carcinoma. Conclusion: Incidence of sebaceous gland carcinoma is more common in India compared to western literature. More aggressive biological behavour was observed in India with metastasis