Transgenic mice with cardiac-specific over-expression of tumor necrosis factor-a (TNF1.6) progress to dilated heart failure. A significant inflammatory response precedes functional deterioration, and may contribute to cardiac damage in this model. To evaluate the underlying molecular mechanisms, we assessed the gene expression in six groups of mouse hearts defined by age, gender, and phenotype (n = 3/group) using Affymetrix microarray analysis. Phenotype was defined as compensated (in young TNF1.6) or decompensated (in older TNF1.6) via echocardiogram. Of the >1000 transcripts altered in the compensated hearts (fold change > 2, P < 0.05 vs. wild-type (WT)), 102 were identified as immune response genes, 20 of which function in antigen presen...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) is controversially discussed in isc...
BACKGROUND AND AIMS: Regional alterations in ventricular mechanical functions are a primary determin...
Tumor necrosis factor (TNF) and interferon gamma (IFN-'y) are pleuripotent cytokines and have m...
<p>Representative images of in situ terminal deoxynucleotidyl transferase-mediated nick-end labeling...
Experimental autoimmune myocarditis (EAM) is a CD4(+) T-cell-mediated model of human inflammatory di...
Experimental autoimmune myocarditis (EAM) is a CD4(+) T-cell-mediated model of human inflammatory di...
Myocardial infarction (MI) is the leading cause of death in the U.S., affecting elderly populations ...
Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and failure....
Myocarditis is a potentially lethal inflammatory heart disease of children and young adults that fre...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
Myocardial infarction (MI) is the leading cause of death in the U.S., affecting elderly populations ...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
Background: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes m...
Background: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes m...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) is controversially discussed in isc...
BACKGROUND AND AIMS: Regional alterations in ventricular mechanical functions are a primary determin...
Tumor necrosis factor (TNF) and interferon gamma (IFN-'y) are pleuripotent cytokines and have m...
<p>Representative images of in situ terminal deoxynucleotidyl transferase-mediated nick-end labeling...
Experimental autoimmune myocarditis (EAM) is a CD4(+) T-cell-mediated model of human inflammatory di...
Experimental autoimmune myocarditis (EAM) is a CD4(+) T-cell-mediated model of human inflammatory di...
Myocardial infarction (MI) is the leading cause of death in the U.S., affecting elderly populations ...
Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and failure....
Myocarditis is a potentially lethal inflammatory heart disease of children and young adults that fre...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
Myocardial infarction (MI) is the leading cause of death in the U.S., affecting elderly populations ...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
Background: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes m...
Background: Inflammation is a key component of cardiac disease, with macrophages and T lymphocytes m...
Cardiovascular diseases are the leading causes of death worldwide. Myocarditis, also termed inflamma...
The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) is controversially discussed in isc...
BACKGROUND AND AIMS: Regional alterations in ventricular mechanical functions are a primary determin...