Iridium-catalyzed hydroamination of allylic amines from aryl amines

1,2-Diamines are a common motif found in many pharmaceutical and bioactive molecules. Current methods to access this functionality tend to be wasteful and involve multiple steps. Therefore, developing methods that access this functionality in an atom-economical and fast process are desirable. It is envisioned that hydroamination, the addition of an amine N–H bond across an unsaturated C–C bond, would allow access to this 1,2-diamine functionality using allylic amines as starting material. This is particularly appealing as the transformation occurs with complete atom economy and gives high value-added nitrogen containing products from feedstocks. We report the intermolecular iridium-catalyzed hydroamination of allylic amines from aryl amines to afford 1,2-diamine products in good to excellent yields. Excellent Markovnikov regioselectivity is observed for both primary and secondary allylic amines, with a variety of functional groups tolerated.Chemistr