Patient-reported physical function is associated with survival following lung resection for NSCLC.

BACKGROUND We investigated the association between preoperative quality of life (QoL) and long-term survival in patients undergoing surgical resection for non-small cell lung cancer (NSCLC). METHODS Retrospective analysis was conducted on 388 consecutive patients who completed the Quality of Life assessment through the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and lung cancer specific module (LC13), prior to anatomical lung resection for NSCLC (2014-2018). Survival distribution was estimated by the Kaplan-Meier method. Cox proportional hazard regression and competing risk regression analyses were used to assess the independent association of preoperative patient-reported outcomes with overall and cancer-specific survival. RESULTS Higher score in patient-reported Physical Functioning was significantly associated with longer overall survival (Figure 1). Factors significantly associated with poorer overall survival remained older age (p=0.005), low BMI (p=0.007), male sex (p