Synthesis and evaluation of phenylboronic and cinnamic acid conjugates : bachelor thesis

Cilj rada je prikazati sintezu i evaluaciju konjugata fenilboronične i cimetne kiseline. Fenilboronična kiselina pripada derivatima borne kiseline. Poznata je po svojim mogućim medicinskim svojstvima te je istraživana kao sredstvo u liječenje raka. Cimetna kiselina je široko zastupljena u biljnom svijetu, a izvor je većine derivata hidroksicimetne kiseline poput kumarinske, kafeinske, ferulinske i sinapinske kiseline. U ovom radu opisane su fenilboronična i cimetna kiselina općenito, njihova kemijska svojstva i strukture, upotreba njihovih derivata, te konačno sinteza fenilboronične i cimetne kiseline. Za potrebe rada korištena je relevantna literatura koja se odnosi na stručne članke i knjige koji su u skladu sa temom rada.The aim of this work is to present the synthesis and evaluation of the conjugate of phenylboronic acid and cinnamic acid. Phenylboronic acid belongs to the derivatives of boric acid. It is known for its potential medicinal properties and has been explored as a treatment for cancer. Cinnamic acid is widely distributed in the plant world and is the source of most hydroxycinnamic acid derivatives such as coumarin, caffeic acid, ferulic acid, and sinapic acid. In this paper, phenylboronic and cinnamic acids in general, their chemical properties and structures, the use of their derivatives and finally the synthesis of phenylboronic and cinnamic acids are described. Relevant literature was consulted for the paper, referring to technical articles and books corresponding to the subject of the paper