Add to ORKGBackground: Human UDP-glucuronosyltransferases (UGTs) are important membrane proteins located in endoplasmic reticulum, and play important roles in metabolism of a variety of endogenous and exogenous compounds. Aims: To determine the influence of subtle difference in the structure of oleanolic acid and betulinic acid towards the inhibition towards the activity of UGT isoforms. Methods: In vitro glucuronidation of 4-methylumbelliferone (4-MU) reaction was employed as the probe reaction to determine the inhibition of these two compounds towards UGTs\u2019 activity. Results: The inhibition of capability of oleanolic acid towards UGT1A6 and UGT1A8 were higher than betulinic acid. However, no significant difference was observed for the inhibitio...
Flavonoids are widely distributed phytochemicals in vegetables, fruits and medicinal plants. Recent ...
We previously reported that [[N-[3β-hydroxyl-lup-20(29)-en-28-oyl]-7-aminoheptyl]-carbamoyl]methane ...
Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metabolism enzym...
Background: Human UDP-glucuronosyltransferases (UGTs) are important membrane proteins located in end...
Background: Drug-metabolizing enzymes (DMEs) inhibition based drug-drug interaction and herb-drug in...
Renal ischaemia is associated with accumulation of fatty acids (FA) and mobilisation of arachidonic ...
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the me...
Strong inhibition of the human UDP-glucuronosyltransferase enzymes (UGTs) may lead to undesirable ef...
Enzyme selective inhibitors represent the most valuable experi-mental tool for reaction phenotyping....
UDP-glucuronosyltransferases (UGTs), the most important phase II drug metabolizing enzymes (DMEs), c...
Background: Inhibition of drug-metabolizing enzymes (DMEs) has been regarded as one of the most impo...
Parthenolide (PTL) and micheliolide (MCL) are sesquiterpene lactones with similar structures, and bo...
Isoliquiritigenin, a herbal ingredient with chalcone structure, has been speculated to be able to in...
Herb-drug interaction strongly limits the clinical application of herbs and drugs, and the inhibitio...
In this study, 22 new betulinic acid (BA) derivatives were synthesized and tested for their inhibiti...
Flavonoids are widely distributed phytochemicals in vegetables, fruits and medicinal plants. Recent ...
We previously reported that [[N-[3β-hydroxyl-lup-20(29)-en-28-oyl]-7-aminoheptyl]-carbamoyl]methane ...
Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metabolism enzym...
Background: Human UDP-glucuronosyltransferases (UGTs) are important membrane proteins located in end...
Background: Drug-metabolizing enzymes (DMEs) inhibition based drug-drug interaction and herb-drug in...
Renal ischaemia is associated with accumulation of fatty acids (FA) and mobilisation of arachidonic ...
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the me...
Strong inhibition of the human UDP-glucuronosyltransferase enzymes (UGTs) may lead to undesirable ef...
Enzyme selective inhibitors represent the most valuable experi-mental tool for reaction phenotyping....
UDP-glucuronosyltransferases (UGTs), the most important phase II drug metabolizing enzymes (DMEs), c...
Background: Inhibition of drug-metabolizing enzymes (DMEs) has been regarded as one of the most impo...
Parthenolide (PTL) and micheliolide (MCL) are sesquiterpene lactones with similar structures, and bo...
Isoliquiritigenin, a herbal ingredient with chalcone structure, has been speculated to be able to in...
Herb-drug interaction strongly limits the clinical application of herbs and drugs, and the inhibitio...
In this study, 22 new betulinic acid (BA) derivatives were synthesized and tested for their inhibiti...
Flavonoids are widely distributed phytochemicals in vegetables, fruits and medicinal plants. Recent ...
We previously reported that [[N-[3β-hydroxyl-lup-20(29)-en-28-oyl]-7-aminoheptyl]-carbamoyl]methane ...
Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metabolism enzym...