Current management of Parkinson's disease

Although Parkinson\u2032s disease (PD) is still incurable, a large number of different treatments have become available to improve the quality of life and physical and psychological morbidity, and its early treatment is of prime importance. This article reviews the current situation of PD. This review was based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. The subject headings and keywords used were Parkinson\u2032s disease and therapeutic advances. Only articles written in English were included.The management of PD has evolved rapidly over the last 10 years with the advent of new drugs and new classes of drugs, but the currently available treatment methods are all symptomatic ones. However, some of these may have marginal disease-modifying effects. Progress in manufacture of newer drugs has markedly improved the treatment of early PD; however, the management of advanced Parkinson\u2032s symptoms remains a challenge. Currently no treatment has been proven to slow the progression of PD. Although symptomatic therapy can provide benefit for many years, PD will eventually result in significant morbidity.Maladie de Parkinson bien (PD) est encore incurable, un grand nombre de traitements diff\ue9rents est devenus disponible pour am\ue9liorer la qualit\ue9 de vie et de la morbidit\ue9 physique et psychologique, et son traitement pr\ue9coce est de premi\ue8re importance. Cet article passe en revue la situation actuelle de PD. Cette r\ue9vision \ue9tait fond\ue9e sur une recherche de Medline, la base de donn\ue9es de Cochrane d\u2019avis syst\ue9mique, et citation des listes de publications pertinentes. Les descripteurs et les mots-cl\ue9s utilis\ue9s \ue9taient la maladie de Parkinson et les progr\ue8s th\ue9rapeutiques. Seulement les articles r\ue9dig\ue9s en anglais ont \ue9t\ue9 incluses. Gestion du PD a \ue9volu\ue9 rapidement les 10 derni\ue8res ann\ue9es avec l\u2019arriv\ue9e de nouveaux m\ue9dicaments et de nouvelles classes de m\ue9dicaments, mais les m\ue9thodes de traitement actuellement disponibles sont tous symptomatiques. Cependant, certains d\u2019entre eux peuvent avoir maladie marginal, modifier les effets. Progr\ue8s dans la fabrication de nouveaux m\ue9dicaments a nettement am\ue9lior\ue9 le traitement pr\ue9coce PD; toutefois, la gestion des sympt\uf4mes de la maladie de Parkinson avanc\ue9e reste un d\ue9fi. Actuellement, aucun traitement n\u2019a \ue9t\ue9 prouv\ue9 \ue0 ralentir la progression du PD. Bien que le traitement symptomatique peut fournir des prestations pendant de nombreuses ann\ue9es, PD aboutira finalement \ue0 morbidit\ue9 significative