Add to ORKGMost of untreated advanced breast cancer patients (BCP, invasive ductal, stage IIIB) develop osteolytic bone metastasis, due to the existence of a pre-metastatic niche (PMN) that favours extravasa tion, migration, and proliferation of tumor cells. We found that bone marrow (BM) mesenchymal stem cells (MSC) from BCP have lower cloning, proliferation, and osteogenic differentiation capacities than healthy donors (HD) MSC. A conserved pool of functional MSC is essential for preventing the PMN formation.Fil: Borzone, Francisco Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; A...
Background: Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly chi...
A challenge in osteosarcoma (OS) is lung metastasis occurrence. OS, a bone marrow (BM)–associated tu...
The bone marrow is a dynamic organ where osteogenesis and bone remodeling take place side by side wi...
Most of untreated advanced breast cancer patients (BCP, invasive ductal, stage IIIB) develop osteoly...
Breast cancer is one of the most common oncological pathologies in women worldwide. While its early ...
Tumour cells can find in bone marrow (BM) a niche rich in growth factors and cytokines that promote ...
The imbalance between osteogenesis and osteoclastogenesis in the bone marrow (BM) microenvironment s...
The imbalance between osteogenesis and osteoclastogenesis in the bone marrow (BM) microenvironment s...
Even though bone marrow mesenchymal stem cells and the “endosteal and vascular hematopoietic niche” ...
Bone metastasis is an incurable complication of breast cancer affecting 70-80 % of advanced patients...
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from wi...
Bone marrow environment (BME) niches are shown to play a role in the development and progression of ...
Bone marrow environment (BME) niches are shown to play a role in the development and progression of ...
Bone marrow environment (BME) niches are shown to play a role in the development and progression of ...
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from wi...
Background: Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly chi...
A challenge in osteosarcoma (OS) is lung metastasis occurrence. OS, a bone marrow (BM)–associated tu...
The bone marrow is a dynamic organ where osteogenesis and bone remodeling take place side by side wi...
Most of untreated advanced breast cancer patients (BCP, invasive ductal, stage IIIB) develop osteoly...
Breast cancer is one of the most common oncological pathologies in women worldwide. While its early ...
Tumour cells can find in bone marrow (BM) a niche rich in growth factors and cytokines that promote ...
The imbalance between osteogenesis and osteoclastogenesis in the bone marrow (BM) microenvironment s...
The imbalance between osteogenesis and osteoclastogenesis in the bone marrow (BM) microenvironment s...
Even though bone marrow mesenchymal stem cells and the “endosteal and vascular hematopoietic niche” ...
Bone metastasis is an incurable complication of breast cancer affecting 70-80 % of advanced patients...
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from wi...
Bone marrow environment (BME) niches are shown to play a role in the development and progression of ...
Bone marrow environment (BME) niches are shown to play a role in the development and progression of ...
Bone marrow environment (BME) niches are shown to play a role in the development and progression of ...
Mesenchymal stem cells (MSCs) are multipotent non-haematopoietic cells primarily originating from wi...
Background: Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly chi...
A challenge in osteosarcoma (OS) is lung metastasis occurrence. OS, a bone marrow (BM)–associated tu...
The bone marrow is a dynamic organ where osteogenesis and bone remodeling take place side by side wi...