Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders
- Moraca F.
- Marzano S.
- D'Amico F.
- Lupia A.
- Di Fonzo S.
- Vertecchi E.
- Salvati E.
- Di Porzio A.
- Catalanotti B.
- Randazzo A.
- Pagano B.
- Amato J.
DOIAbstract
The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders
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