Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay
- Xuwen Gao (375540)
- Xiancheng Liu (424379)
- Ying Zeng (321269)
- Qingqing Zhang (458374)
- Bin Zhang (64682)
- Guizheng Zou (1412527)
DOIAbstract
The investigation on electrochemiluminescence (ECL) multiplexing bioassays mainly focuses on simultaneously detecting either proteins or nucleic acids. To overcome the limitation of a short waveband for spectrum-resolved ECL multiplexing bioassays, herein, a highly monochromatic (FWHM <40 nm) and bandgap-engineered ECL luminophore, that is, mercaptopropionic acid-capped and Zn2+-mediated aggregation-induced emission (AIE) assembly of Au nanocrystals (NCs) (Zn2+-AIE-AuNCs), of strong emission and the maximum emission wavelength at 485 nm is developed. The highly monochromatic and bandgap-engineered ECL (485 nm) of Zn2+-AIE-AuNCs can multiplex with the single-waveband and surface-defect-involved ECL (775 nm) of dual-stabilizer-capped CuInS2@Z...
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