Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucial in organ donation, risk assessment of autoimmune and infectious diseases and cancer immunotherapy. However, due to the high genetic polymorphism in this region, HLA typing requires specialized methods. We investigated the performance of five next-generation sequencing (NGS) based HLA typing tools with a non-restricted license namely HLA*LA, Optitype, HISAT-genotype, Kourami and STC-Seq. This evaluation was done for the five HLA loci, HLA-A, -B, -C, -DRB1 and -DQB1 using whole-exome sequencing (WES) samples from 829 individuals. The robustness of the tools to lower depth of coverage (DOC) was evaluated by subsampling and HLA typing 230 WES s...
Allele-level resolution data at primary HLA typing is the ideal for most histocompatibility test-ing...
Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification...
BackgroundThe Human Leukocyte Antigen (HLA) genes are a group of highly polymorphic genes that are l...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Next-Generation Sequencing (NGS) has transformed clinical histocompatibility laboratories through it...
Specific HLA genotypes are known to be linked to either resistance or susceptibility to certain dise...
Abstract Background The adaptive immune response intrinsically depends on hypervariable human leukoc...
Human leukocyte antigen (HLA) genotyping gains intensive attention due to its critical role in cance...
Matching for hla at the allele level is crucial for stem cell transplantation. The golden standard a...
Specific HLA genotypes are known to be linked to either resistance or susceptibility to certain dise...
Allele-level resolution data at primary HLA typing is the ideal for most histocompatibility test-ing...
Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification...
BackgroundThe Human Leukocyte Antigen (HLA) genes are a group of highly polymorphic genes that are l...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucia...
Next-Generation Sequencing (NGS) has transformed clinical histocompatibility laboratories through it...
Specific HLA genotypes are known to be linked to either resistance or susceptibility to certain dise...
Abstract Background The adaptive immune response intrinsically depends on hypervariable human leukoc...
Human leukocyte antigen (HLA) genotyping gains intensive attention due to its critical role in cance...
Matching for hla at the allele level is crucial for stem cell transplantation. The golden standard a...
Specific HLA genotypes are known to be linked to either resistance or susceptibility to certain dise...
Allele-level resolution data at primary HLA typing is the ideal for most histocompatibility test-ing...
Although NGS technologies fuel advances in high-throughput HLA genotyping methods for identification...
BackgroundThe Human Leukocyte Antigen (HLA) genes are a group of highly polymorphic genes that are l...