Additional file 1: Figure S1. Female RAGE deficiency improved glucose and insulin tolerance in normal diet mice. (A) Glucose tolerance tests (GTT) and Area under the curve (AUC) in each group. n = 6 per group. *p < 0.05 vs. female RAGE−/−-HFD-F mice; #p < 0.05 vs. female RAGE−/−-ND-F mice. (B) Insulin tolerance tests (ITT) and AUC in each group. n = 6 per group. *p < 0.05 vs. female RAGE−/−-HFD-F mice; #p < 0.05 vs. female RAGE−/−-ND-F mice. ND; normal diet. All group data are shown as mean ± SEM
Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...
Figure S3. Sex-dependent FAs and TGs profile in gAT and iAT of ob/ob mice. Relative t-SNE plot of (A...
Figure S4. Hepatic gene expression levels in F WT (♀ pink bullets), M WT (♂ blue triangles), F ERαKO...
Male mice have increased plasma insulin levels on HFD. Column graphs showing plasma insulin levels i...
Crhr2+/− male mice gain more body mass. Line graphs showing weekly change in body mass in male (n = ...
Blood glucose levels in response to insulin challenge in Crhr2+/− mice. In ITT, blood glucose levels...
Effects of diet treatments on blood levels of glucose and insulin. BALB/c mice started on HFD or LFD...
Sex-specific fat mass gain and/or redistribution on chow vs. HFD. Column bar graphs showing fat mass...
High-fat diet (HFD) feeding increases mammary adipocyte size and inflammation. A C57Bl/6 female mice...
Crhr2+/− male mice have elevated baseline blood glucose levels. In GTT, blood glucose was measured b...
Weekly food intake in mice. Column bar graphs showing weekly average food intake per mouse in g/ g b...
Male mice have increased plasma lipid levels. Column bar graphs showing plasma lipid profiles in mal...
Figure S1. Long-term exposure to HFD induces obesity, insulin resistance and hyperglycemia in A7-Tg ...
Negative controls used for UCP1 immunostaining in Fig. 1c. Figure S2. The induction of brown adipoc...
Figure S1. Ins2Akita mice had markedly higher blood glucose levels. Blood glucose concentration (mg/...
Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...
Figure S3. Sex-dependent FAs and TGs profile in gAT and iAT of ob/ob mice. Relative t-SNE plot of (A...
Figure S4. Hepatic gene expression levels in F WT (♀ pink bullets), M WT (♂ blue triangles), F ERαKO...
Male mice have increased plasma insulin levels on HFD. Column graphs showing plasma insulin levels i...
Crhr2+/− male mice gain more body mass. Line graphs showing weekly change in body mass in male (n = ...
Blood glucose levels in response to insulin challenge in Crhr2+/− mice. In ITT, blood glucose levels...
Effects of diet treatments on blood levels of glucose and insulin. BALB/c mice started on HFD or LFD...
Sex-specific fat mass gain and/or redistribution on chow vs. HFD. Column bar graphs showing fat mass...
High-fat diet (HFD) feeding increases mammary adipocyte size and inflammation. A C57Bl/6 female mice...
Crhr2+/− male mice have elevated baseline blood glucose levels. In GTT, blood glucose was measured b...
Weekly food intake in mice. Column bar graphs showing weekly average food intake per mouse in g/ g b...
Male mice have increased plasma lipid levels. Column bar graphs showing plasma lipid profiles in mal...
Figure S1. Long-term exposure to HFD induces obesity, insulin resistance and hyperglycemia in A7-Tg ...
Negative controls used for UCP1 immunostaining in Fig. 1c. Figure S2. The induction of brown adipoc...
Figure S1. Ins2Akita mice had markedly higher blood glucose levels. Blood glucose concentration (mg/...
Figure S6. HFD feeding on IRS-2-deficient A7-Tg mice exacerbates diabetic phenotype. a Effect of HFD...
Figure S3. Sex-dependent FAs and TGs profile in gAT and iAT of ob/ob mice. Relative t-SNE plot of (A...
Figure S4. Hepatic gene expression levels in F WT (♀ pink bullets), M WT (♂ blue triangles), F ERαKO...