The study of antiepileptic activity of clove oil in chemical induced convulsions in mice

Background: The objective was to evaluate and compare the effect of an extract of essential oil of clove with the standard sodium valproate on pentylenetetrazole (PTZ) induced seizures in animal models.Methods: A total of 30 mice were taken, they were given a chemo shock at the concentration of 60 mg/kg using PTZ. 30 mice were divided into 5 groups of 6 animals each the control group received distilled water 5 ml/kg i.p., standard received injection sodium valproate 200 mg/kg i.p. another group received sesame oil – 10 ml/kg i.p. (control), test groups received Clove oil - 0.075 ml/kg i.p., clove oil - 0.1 ml/kg i.p., respectively. All the injections were given 30 mins before the administration of PTZ.Results: Clove oil produced a significant antiepileptic effect at all the doses.Conclusion: Clove oil has shown significant antiepileptic activity in mice