Expression of VEGF in breast cancer

Background: To evaluate the expression of Vascular Endothelial Growth Factor in breast cancer patients. Materials & methods: A total of 40 patients were enrolled. Mean age of the patients was 47.5 years. Biopsy specimens were obtained and were subjected with H and E staining. For VEGF marker, IHC staining was done. Segregation of subjects was done on the basis of VEGF expression. Univariate analysis was done for assessing the factors associated with positive expression of VEGF in breast cancer. All the results were recorded and were analysed using SPSS software. Results: A total of 40 patients were enrolled. Mean BMI was 25.5 kg/m2 . Majority had a positive expression of VEGF. Positive smoking history with positive VEGF was 20 and showed significant p- value. Positive family history of cancer and mean tumour size were also significant. Conclusion: Breast cancer patients are associated with enhanced expression of VEGF