Add to ORKGToxicities to healthy tissues, which can be particularly invalidating for patients, are the main limitations of the therapeutic efficacy of radiotherapy. Macrophages may play a role in these toxicities, but their modes of action and recruitment remain elusive. Monocytes interact with the vascular endothelium to enter the tissue and differentiate into macrophages. The endothelium shows multiple responses to irradiation and participates in the development of complications. The objective of this thesis is to study the role of endothelial actors regulating radiation-induced monocyte recruitment. For this purpose, we developed and used real-time in vitro imaging techniques to model two steps of the recruitment process: adhesion under flow condit...