Raman spectroscopy of blood plasma for cancer diagnosis

Raman spectra of blood plasma were studied in the dynamics of the experimental glioma. We used a DXR Raman Microscope (Thermo Scientific), excitation wavelengths of 532 nm, range 80–3200 cm–1. Each sample of blood plasma was a droplet with a volume of 10 μL placed on a special aluminum plate. Machine learning methods were used to identify the most informative frequencies associated with cancer molecular markers. The most significant changes in the Raman spectra are observed in the 900–1700 cm–1 range