Cytogenetic and loss of heterozygosity (LOH) studies demonstrated chromosome 3p deletions in transitional cell carcinoma (TCC), We recently cloned the tumor suppressor gene FNIT (fragile histidine triad) at 3p14.2, one of the most frequently deleted chromosomal regions in TCC of the bladder, and showed that it is the target of environmental carcinogens. Abnormalities at the FHIT locus have been found in tumors of the lung, breast, cervix, head and neck, stomach, pancreas, and clear cell carcinoma of the kidney. We examined six TCC derived cell lines (SW780, T24, Hs228T, CRL7930, CRL7833, and HTB9) and 30 primary TCC of the bladder for the integrity of the FHIT transcript, using reverse transcriptase-polymerase chain reaction (RT-PCR) to inv...
Evidence for alteration of the FHIT gene in a significant fraction of breast carcinomas has been rep...
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in s...
A variety of studies suggests that tumor suppressor loci on chromosome 3p are important in various f...
The fragile histidine triad (FHIT) gene located on chromosome 3p14.2 is frequently deleted in human ...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
Chromosome 3p deletions in breast cancer have been detected at 3p12-p21 by cytogenetic and loss of h...
Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of th...
The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile...
AbstractA 200–300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozyg...
BACKGROUND: Genomic alterations and abnormal expression of the FHIT gene have been reported for a nu...
The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, i...
The FHIT gene is located at a chromosomal site (3p14.2) which is commonly affected by translocations...
The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm...
Evidence for alteration of the FHIT gene in a significant fraction of breast carcinomas has been rep...
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in s...
A variety of studies suggests that tumor suppressor loci on chromosome 3p are important in various f...
The fragile histidine triad (FHIT) gene located on chromosome 3p14.2 is frequently deleted in human ...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
Chromosome 3p deletions in breast cancer have been detected at 3p12-p21 by cytogenetic and loss of h...
Chromosomal or allelic losses at 3p14 are common in a variety of human tumors, including those of th...
The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile...
AbstractA 200–300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozyg...
BACKGROUND: Genomic alterations and abnormal expression of the FHIT gene have been reported for a nu...
The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, i...
The FHIT gene is located at a chromosomal site (3p14.2) which is commonly affected by translocations...
The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm...
Evidence for alteration of the FHIT gene in a significant fraction of breast carcinomas has been rep...
Frequent loss of heterozygosity in head and neck squamous cell carcinoma (HNSCC) has been found in s...
A variety of studies suggests that tumor suppressor loci on chromosome 3p are important in various f...