Association of the Q121 Variant of ENPP1 Gene With Decreased Kidney Function Among Patients With Type 2 Diabetes

S., De Cosmo
A., Minenna
Y. Y., Zhang
R., Thompson
G., Miscio
M., Vedovato
A., Rauseo
A., Saller
S., Mastroianno
F., Pellegrini
R., Trevisan
P., Fioretto
A., Doria
Trischitta, Vincenzo

Open link

Publication date

January 2009

DOI

10.1053/j.ajkd.2008.07.040

Publisher

Elsevier BV

ISSN

0272-6386

Citation count (estimate)

Abstract

Background: Insulin resistance has a role in diabetic kidney complications. The K121Q (lysine to glutamine substitution at amino acid 121, encoded by single-nucleotide polymorphism rs1044498) variant of the ectonucleotide pyrophosphatase/phosphodiesterase gene (ENPP1) has been associated with insulin resistance and related vascular complications in patients with type 2 diabetes (T2D) in many, although not all, studies. This study investigated whether the ENPP1 Q121 variant modulates the risk of decreased glomerular filtration rate (GFR) in patients with T2D. Study Design: Cross-sectional study. Setting & Participants: 2 diabetes units from Italy (in Gargano and Padua) and 1 from the United States (Boston, MA) recruited a total of 1,392 pati...